SPOT-MAS 10 Multi-Cancer Early Detection Test
A next-generation blood test that screens for DNA fragments linked to 10 common cancers in Singapore.
With a simple blood draw, take a proactive step toward understanding your cancer risk and timely follow-up.
Early detection begins with awareness—consult our doctor today.
What is SPOT-MAS 10?
SPOT-MAS 10 is a laboratory-developed, non-invasive blood test designed for multi-cancer early detection (MCED). It uses next-generation sequencing and AI-powered analysis to examine circulating tumor DNA (ctDNA) in your bloodstream — even before symptoms may appear.
Through a single blood draw, SPOT-MAS 10 evaluates multiple DNA features to identify potential cancer-related signals:
DNA methylation patterns
Fragment length distribution
Copy number alterations (CNAs)
If abnormal signals are detected, the test may also predict the most likely tissue of origin, helping clinicians recommend appropriate next steps.
Cancers Screened by SPOT-MAS 10
SPOT-MAS 10 is designed to screen for signals associated with 10 types of cancers commonly found in Singapore, including:
Lung
(Small cell lung cancer, Non-small cell lung cancer)
Colorectum
Stomach
Liver
Biliary tract
Head & Neck
Esophagus
Pancreas
Breast
Ovary
Uterus
By analyzing tumor DNA fragments in the blood, the test supports earlier identification of potential cancer signals before symptoms arise.
SPOT-MAS 10 at a Glance
Accurate
78.1% sensitivity, 99.8% specificity, and 84% tissue origin accuracy — delivering reliable cancer detection you can trust.
Comprehensive
Screens for 10 common cancers frequently found in Singapore
Analysis of Tumor DNA Fragments
Analyzes circulating tumor DNA (ctDNA) fragments in the bloodstream to identify potential cancer signals
Simple Blood Collection
Requires only a single blood draw during a routine health visit
What Happens During the SPOT-MAS 10 Testing Process?
Our 3-step process during the SPOT-MAS test is designed to be simple, seamless, and scientifically rigorous—so you can focus on your health, not the hassle.
1. Consultation & Blood Collection
Begin by speaking with your doctor at Wonderhealth. If the test is suitable for you, a simple 10ml blood sample will be collected during your visit. No special preparation is needed; just book your screening and show up.
2. Advanced DNA Analysis
Your sample is sent to a dedicated genomics laboratory in Singapore. Using next-generation sequencing and AI-powered analysis, the lab examines circulating tumor DNA (ctDNA) to detect abnormal patterns, such as methylation, fragment length, and genomic alterations linked to 10 common cancers.
3. Results & Review
You’ll receive your results in about 12–18 working days after the lab receives your sample. Once ready, your doctor will walk you through the findings and, if necessary, recommend further diagnostic steps tailored to your health profile.
Benefits of SPOT-MAS 10 Multi-Cancer Early Detection Test
Early Detection of Multiple Cancers
Identifies cancers in early stages when treatment is most effective.
Minimal Disruption
Non-invasive, quick, and requires no downtime or recovery.
Comprehensive Insights
Covers multiple types of cancer in a single test, unlike conventional screenings that target specific cancers.
Personalized Follow-Up
Test results are reviewed by experienced medical professionals who provide tailored recommendations.
Who Should Consider SPOT-MAS 10?
SPOT-MAS 10 is ideal for individuals who:
Have a family history of cancer.
Are at higher risk due to lifestyle factors or environmental exposures.
Seek a proactive approach to health management.
Prefer a non-invasive screening method.
4X Higher Survival with Early Diagnosis
Breast and Colorectal cancers have >90% survival rate if detected early.
Less expensive treatment if diagnosed early.
Who Should Not Take the SPOT-MAS 10 Test?
While SPOT-MAS 10 is a powerful tool for proactive cancer screening, it may not be suitable for certain individuals. Please consult your doctor if any of the following apply:
You’ve had cancer within the last 5 years.
The SPOT-MAS test is designed for early detection, not for monitoring previously diagnosed cancers or those in remission.
You’re currently experiencing symptoms suggestive of cancer.
These include unexplained weight loss, persistent pain that doesn’t respond to medication, abnormal bleeding or discharge (e.g. from the nipple), prolonged coughing, or noticeable changes in bowel habits. Diagnostic evaluation is more appropriate in these cases.
You are pregnant.
Due to physiological changes during pregnancy, this test is not recommended for expectant mothers.
You’ve recently received a bone marrow transplant or whole blood transfusion.
If this occurred within the past 3 months, it may interfere with the accuracy of ctDNA analysis.
Why Screen for Cancer Early?
What To Expect During Your SPOT-MAS 10 Screening?
1. Schedule Your Appointment
2. Visit The Clinic
3. Receive And Discuss Your Results
Your results will be ready in approximately 12 to 18 days. Once available, your doctor will walk you through the findings and recommend next steps, if necessary.
SPOT-MAS 10 Cancer Screening
10 Cancer Types- Lung (Small cell lung cancer, Non-small cell lung cancer)
- Colorectum
- Stomach
- Liver-Biliary tract
- Head & Neck
- Esophagus
- Pancreas
- Breast
- Ovary
- Uterus
Frequently Asked Questions About SPOT-MAS 10 Cancer Screening
What is the SPOT-MAS 10 Test?
Why is Early Cancer Detection Important?
Detecting cancer at an earlier stage often allows for more effective treatment options and better outcomes. Early detection may increase the chances of managing the condition before it progresses, supporting improved quality of life and long-term health.
What Cancers Can SPOT-MAS 10 Screen For?
SPOT-MAS 10 is designed to screen for signals associated with the following 10 cancer types:
Lung
Breast
Colorectal
Stomach
Liver & Biliary Tract
Uterine
Esophageal
Ovarian
Pancreatic
Head & Neck
These are among the most commonly occurring cancers. The test is suitable for both men and women and supports earlier medical evaluation when potential signals are present.
How is the SPOT-MAS 10 Test Conducted?
The SPOT-MAS 10 test involves a single blood draw, typically done during a routine clinic visit. The sample is then sent to a specialized laboratory, where it is analyzed for circulating tumor DNA (ctDNA) that may indicate the presence of cancer-related signals.
Results are typically available within 12 to 18 working days, after which further clinical consultation may be recommended if necessary.
How Accurate is the SPOT-MAS 10 Test?
SPOT-MAS 10 has been clinically validated in studies involving over 11,000 participants. It shows high accuracy as a screening tool, with the following performance indicators:
Overall sensitivity: 78.1%
Sensitivity for early-stage cancers: 65.2%
Sensitivity for Stage IIIA: 88.3%
Specificity: 99.8% (low false-positive rate)
Positive Predictive Value (PPV): 58.1% (higher in males: 81.0%)
Negative Predictive Value (NPV): 99.9%
Tissue-of-origin accuracy: 84.0% when a signal is detected
Note: A positive result does not confirm cancer and should be followed by further diagnostic evaluation with your doctor.
Who Should Consider the SPOT-MAS 10 Test?
SPOT-MAS 10 is generally recommended for individuals aged 40 and above, especially those with elevated cancer risk. This includes people with:
A history of heavy smoking (e.g., ≥20 pack-years)
Frequent alcohol consumption (e.g., ≥15 cans of beer/week for men, ≥8 for women)
Genetic predisposition (e.g., BRCA1, BRCA2, TP53 mutations)
Chronic liver conditions, such as Hepatitis B or C
A family history of cancer
Speak with a healthcare professional to determine if this screening is appropriate for you.
Is SPOT-MAS 10 Appropriate for Younger Individuals?
While SPOT-MAS 10 is primarily recommended for those aged 40 and above, it may also be considered for younger individuals who have:
A strong family history of cancer
Known genetic mutations associated with higher cancer risk
Chronic medical conditions such as Hepatitis B or C
Other clinically identified high-risk factors
It’s best to consult a healthcare provider to assess suitability based on personal risk profile.
What Happens If the Test Detects a ctDNA (Positive) Signal?
If SPOT-MAS 10 detects circulating tumor DNA (ctDNA) signals:
Additional diagnostic tests, such as imaging studies, will be needed to confirm the presence of cancer.
Your healthcare provider will discuss the results and recommend appropriate follow-up investigations.
The test result is a screening indicator, not a definitive diagnosis.
Early consultation helps guide timely and informed medical decisions.
How Often Should I Get Tested with SPOT-MAS 10?
It is generally recommended to consider testing annually, especially for individuals with higher cancer risk.
Your healthcare provider may advise a different testing schedule based on your personal health profile and risk factors.
Regular screening supports ongoing monitoring but should be combined with other recommended health checks.
Can SPOT-MAS 10 Replace Existing Cancer Screening Programs?
SPOT-MAS 10 is intended to complement existing cancer screening methods.
It is not a replacement for established screening programs such as mammograms, colonoscopies, or Pap smears.
The test should be used alongside other recommended screenings as part of a comprehensive health plan.
Always follow your doctor’s advice on appropriate cancer screening for your individual needs.